Sign up to the newsletter Skinceuticals

To be informed about our news, discover
in preview our last novelties
and the last esthetic trends

* Note: All Marketing Communications will be sent in accordance with our Privacy Statement which can be found at . You may elect to opt-out of any Marketing Communications at any time.

Discoloration Defense


Discoloration Defense

Corrective serums

High-potency serum that targets visible skin discoloration for brighter, more even-looking skin

SKIN TYPES: Normal, Oily, Combination, Dry,

SKIN CONDITIONS: Hyperpigmentation,


HbListOfCRecordOperation|158 |
100% authenticity guaranteed

Ensure your SkinCeuticals products are always authentic.
Learn More.

Your skin deserves safe, effective formulations. Always purchase genuine SkinCeuticals products.
Ensure your SkinCeuticals products are authentic by purchasing through an authorized retailer.
Learn More

Product details

Discoloration Defense is a high-potency dark spot corrector clinically proven to reduce the appearance of key types of skin discoloration in all skin tones, including hard-to-treat forms such as stubborn brown patches and post-acne marks. Formulated with 3% tranexamic acid, 1% kojic acid, 5% niacinamide, and 5% HEPES, These 4 ingredients each target a different step of discoloration formation in the skin, to fade and prevent stubborn pigments from reoccurring, brighten skin, and even skin tone in as early as 2 weeks*.
  • Fades stubborn brown patches, such as melasma
  • Minimizes the recurrence of discoloration (with continued use)
  • Accelerates cell renewal and enhances skin luminosity
  • Suitable for any skin type
  • Paraben-, fragrance-, silicone-, gluten-, and hydroquinone-free
  • Ideal at-home complement to professional skin discoloration treatments, such as chemical peels or non-ablative laser; always consult with a physician for individual regimen recommendations
*Self-assessment in Brazil, 55 women Fitzpatrick I-IV, after 12 weeks, twice daily application in conjunction with sunscreen.

Does the color of Discoloration Defense affect its efficacy?
  • The color of Discoloration Defense varies depending on the product batch, storage, and delivery conditions. This is a normal phenomenon and will not affect the quality and efficacy of the product, nor will this stain the skin. The formula of the product remains stable for 36 months if unopened and 6 months after opening (within the product shelf life). Therefore, please rest assured that the serum is safe to use.

How to use

Twice daily, apply 3-5 drops to face. For morning use, first apply a Vitamin C serum, followed by Discoloration Defense and then a broad spectrum SPF 50+ sunscreen. Limit sun exposure while using this product.

Visible results

In a 12-week clinical study, Discoloration Defense significantly improved the appearance of key skin discoloration markers:

  • 60% average improvement in the appearance of stubborn brown patches
  • 59% average improvement in the appearance of skin discoloration
  • 81% average improvement in the appearance of post-acne marks
  • 59% average improvement in the appearance of uneven skin tone

See ProtocolAverage results shown. Clinical grading in Brazil , 55 women, Fitzpatrick I-IV, after 12 weeks, twice daily application in conjunction with sunscreen. (Number of test subject for stubborn spot: 48)


Science & proof

Everyday elements—including UV exposure, prescription drugs, and some professional treatments—can trigger production of melanin in the skin’s lowest epidermal layers. This excess melanin rises to the surface of the skin, causing visible skin discoloration. Discoloration can manifest in a range of ways, including post-acne marks and stubborn brown patches on the cheekbones, forehead, and upper lip.

Discoloration Defense is the latest-generation dark spot corrector, using a combination of potent and proven anti-discoloration ingredients—including tranexamic acid—to address key types of skin discoloration.


Key Ingredients

    Skin Ceuticals

    Your browser isn't supported

    You can download a new browser :

    Firefoxgoogle chromeoperainternet explorer